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We have the privilege to work with founders and teams at the most innovative and game-changing companies.

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their stories

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April 2, 2024

Pioneering Success: Calypso’s journey to a successful exit

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Case studies

read
their stories

View all cases
April 2, 2024

Pioneering Success: Calypso’s journey to a successful exit

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overview

RespiQ is developing a non-invasive, AI-enhanced breathalyzer for real-time health monitoring at home or point of care, focusing on detecting biomarkers for specific health issues through daily breath analysis. Their technology aims to provide early warnings for health issues, enabling personalized health management and improving overall well-being.
Neolook specializes in offering video-augmentation services to support bonding and family connections in neonatal and pediatric care. Their platform, S2S, includes solutions for family engagement, academic research, and professional integration into existing medical devices and equipment, aiming to enhance clinical practice and scientific advancement through technology.
Tagworks Pharmaceuticals specializes in developing Click-to-Release technology for in vivo click chemistry, aiming to enhance efficacy and reduce toxicity in systemic treatments. Their technology focuses on controlled drug release, notably improving the therapeutic utility of potent systemic therapies, such as antibody-drug conjugates within the tumor microenvironment.
Scoozy introduces a modern mobility scooter designed to provide users with confidence for an active lifestyle, featuring a joystick for easy steering and designed for comfort over various terrains with a focus on safety and style. They aim to transform mobility into a source of joy, drawing inspiration from their roots in the Nuon Solar Challenge to innovate the world of mobility scooters.
Meatable is pioneering the development of lab-grown meat using a proprietary platform that initiates the natural process of muscle and fat growth, starting from a single animal cell. Their technology promises to deliver real meat without the need to raise and slaughter animals, making it a groundbreaking step towards a more sustainable food system.
Toxys is a Dutch biotech company that specializes in providing innovative in vitro toxicity screening solutions, designed to rapidly identify hazardous and potential carcinogenic properties of new compounds during the early phases of product and drug development. Their services aim to help customers make informed decisions in the drug development pipeline, reducing the need for animal testing and contributing to the creation of safer medicines and products.
Vitestro develops autonomous blood drawing technology aimed at transforming patient care by reducing healthcare workers' workload and ensuring accurate, secure blood collection through AI and robotic innovation. Their device combines AI-based, ultrasound-guided imaging with robotic needle insertion, fully automating the blood drawing process from tourniquet application to bandaging, enhancing patient experience and clinical efficiency.
XOSIGHT specializes in real-time AI vision technology for inventory and operations management, utilizing AI-powered vision devices to track inventory and monitor warehouse operations efficiently. Their technology focuses on improving accuracy and performance through early error detection and seamless integration with edge computing, ensuring flexibility in dynamic environments.
ShanX Medtech is developing KAIROS, a groundbreaking in-specimen device aimed at revolutionizing the way bacterial infections are diagnosed and treated by providing quick, evidence-based antibiotic susceptibility testing (AST) and diagnostics (Dx). This technology aims to enable healthcare providers to prescribe the correct antibiotic treatment promptly, addressing the challenge of antimicrobial resistance (AMR) and improving patient outcomes.
Tessellate Bio is focused on redefining synthetic lethality in cancer treatment, aiming to extend beyond traditional homologous recombination deficiency targets to address areas of high medical need with new approaches. They combine cutting-edge research with drug development expertise to create a pipeline of first-in-class medicines, emphasizing tumor-agnostic treatments and precision medicine.
GreenIPP is a European Renewable Energy Development & Investment company that facilitates green power-producing projects across the continent. They serve as a one-stop service company for roof and landowners looking to rent out their property for green energy production, leveraging an extensive international network and strong local partnerships to offer comprehensive solutions throughout the entire supply chain.
Hybridize Therapeutics focuses on developing kidney-targeted RNA-based therapies for patients with acute and chronic kidney diseases, aiming to protect kidneys with high target specificity. Their approach leverages RNA therapeutics' power for cell type specific delivery, particularly improving the therapeutic window for untreated kidney diseases.
Onera Health is redefining sleep diagnostics and monitoring with its first self-applied, no-wire Polysomnography solution, the Onera Sleep Test System (STS). This patch-based sensor system captures all necessary signals for comprehensive sleep analysis, offering gold-standard, clinical-grade diagnostics and monitoring from the comfort of home or in clinical settings.
Caelus Health is a biotech company dedicated to developing microbiota-based products for the prevention and treatment of cardiometabolic disorders, including diabetes. They focus on the commercialization of interventions through a solid preclinical and early-stage clinical development approach, utilizing in-depth knowledge of the microbiome to address unmet medical needs.
Xinvento is dedicated to improving the lives of individuals with congenital hyperinsulinism by researching and developing credible alternative treatments. Their goal is to enhance accessibility to modern medicine for these patients, thus improving the quality of life for both the patients and their caregivers.
Pro Parents supports working parents and their employers by providing tools such as coaching, training, and expert networks to help balance work and family life. They aim to foster inclusive workplaces through personalized technology and specialist support, enhancing satisfaction and productivity for today's and tomorrow's working parents.
NecstGen, the Netherlands Center for the Clinical Advancement of Stem Cell and Gene Therapies, operates a state-of-the-art facility focused on the development and GMP manufacturing of cell and gene therapies. They support a wide range of organizations, from academic to industrial therapy developers, in translating research and early-stage clinical programs into treatments.
VitroScan is a Dutch life sciences company that specializes in providing predictive testing solutions using ex vivo 3D micro tumor testing to evaluate patients' sensitivity to therapeutics. Their technology integrates advanced tumor testing within the native tumor microenvironment and AI algorithms to enhance drug efficacy evaluation and patient stratification for clinical trials, aiming to support the development of novel therapies.
Citryll is a Dutch biotech company focusing on innovative treatments for autoimmune and other inflammatory diseases by targeting and inhibiting the formation and effects of neutrophil extracellular traps (NETs). Their main therapeutic candidate, CIT-013, is a human antibody designed to interfere with NET formation and promote their clearance, offering potential treatments for conditions like lupus, rheumatoid arthritis, and vasculitis.
Phosphoenix is a pioneering medical device startup dedicated to restoring functional and life-enhancing vision to individuals who are blind due to non-functional retinas or optic nerves by developing a visual prosthesis that interfaces directly with the brain. Leveraging breakthroughs in electrode design and microelectronics from decades of neuroscientific research, they aim to enable blind people to identify objects, navigate independently, and regain autonomy in daily life.
Pan Cancer T is an immunotherapy company focused on developing next-generation TCR-T cell therapies for treating solid cancers. Their innovative approach leverages genetically modified T cells aimed at unique tumor-selective targets, with a pipeline that includes treatments for multiple solid tumors, promising more durable clinical responses.
Bilihome offers an innovative solution for jaundiced newborns through a wearable phototherapy device, allowing babies to receive essential treatment while maintaining natural care routines like breastfeeding and skin-to-skin contact. This approach not only supports the health and recovery of the newborn but also won the Red Dot: Best of the Best award for its groundbreaking design in wearable technology.
Spatium Medical, an innovative spin-off from Erasmus MC in Rotterdam, is developing the next generation of insufflation technology aimed at enhancing surgical procedures. Their focus on advanced insufflation methods highlights their commitment to improving clinical outcomes and patient safety in the operating room.
Scenic Biotech is dedicated to harnessing the potential of genetic modifiers for the development of innovative treatments targeting cancer and rare genetic diseases. By exploring the body's intrinsic defense mechanisms against these conditions, their cutting-edge research aims to pave the way for groundbreaking therapeutics that could significantly impact patient care.
eSIM Go empowers businesses of all sizes to offer their own digital connectivity solutions quickly and easily, leveraging eSIM technology to meet the changing communication needs. They provide API integration for mobile connectivity across 1,000 networks in over 150 countries, supporting industries like travel, fintech, and enterprise with flexible global connectivity options.
20Med Therapeutics is advancing the field of non-viral drug delivery with their proprietary bio-responsive polymeric nanoparticles (PNPs), designed for effective delivery of RNA and DNA payloads. They are focused on developing RNA and DNA-based vaccines and therapeutics, aiming to improve global access to medical innovations and address the distribution inequities, with a platform that offers significant advantages in manufacturing scalability, stability, and immunogenicity.
Solynta is pioneering in the field of potato breeding with its innovative hybrid potato breeding technology, which unlocks the true potential of potatoes, enhancing their nutritional value through new hybrid varieties. This technology aims to improve global food security and grower well-being by enabling the rapid development of potatoes with improved characteristics, such as increased disease resistance and yield.
Delta Diagnostics is focused on making label-free, multiplexed biosensing technology accessible and affordable for all types of research, aiming to accelerate scientific discovery by providing faster, more efficient data gathering from precious samples. By integrating photonic integrated circuits, they offer a solution that significantly speeds up research workflows and reduces the cost of ownership, thus democratizing high-performance label-free detection for a wide range of scientific fields.
Emproof specializes in providing advanced security solutions for embedded systems, ensuring high levels of software security and intellectual property integrity through their product, Emproof Nyx. This technology protects against reverse engineering and exploitation attacks across various industries, including Industrial IoT, semiconductors, automotive, aviation, and healthcare, by securing devices throughout their lifecycle.
Prolira specializes in the early detection and monitoring of acute encephalopathy and delirium with their DeltaScan® Brain State Monitor, offering a rapid and objective measurement that has a high diagnostic value for timely interventions. This technology aims to improve healthcare for older patients by enabling earlier and more accurate diagnosis of these conditions, which are common post-operative complications and can significantly impact patient outcomes.
Orthros Medical is a Dutch biotech company specializing in developing therapeutics and diagnostics for both animal and human health, with a focus on osteoarthritis. They utilize VHH-based (single chain antibodies) technology to explore new treatments and diagnostics, leveraging the unique properties of VHH for potential new local treatments.
CardiacBooster is focused on developing the next generation of percutaneous left ventricular assist devices, aiming to minimize organ damage and increase survival chances after heart attacks. They are part of the Medtech Innovator Accelerator Class of 2021, reflecting their innovative approach to enhancing cardiac support technologies.
Audion Therapeutics is a clinical-stage biopharmaceutical company dedicated to developing therapies for hearing loss, focusing on restoring hearing function through targeting the gamma secretase protein complex. Their lead product candidate has completed early clinical studies, showing safety and initial indications of efficacy in patients with sensorineural hearing loss.
XOSIGHT specializes in real-time AI vision technology for inventory and operations management, utilizing AI-powered vision devices to track inventory and monitor warehouse operations efficiently. Their technology focuses on improving accuracy and performance through early error detection and seamless integration with edge computing, ensuring flexibility in dynamic environments.
Bilihome offers an innovative solution for jaundiced newborns through a wearable phototherapy device, allowing babies to receive essential treatment while maintaining natural care routines like breastfeeding and skin-to-skin contact. This approach not only supports the health and recovery of the newborn but also won the Red Dot: Best of the Best award for its groundbreaking design in wearable technology.
Scoozy introduces a modern mobility scooter designed to provide users with confidence for an active lifestyle, featuring a joystick for easy steering and designed for comfort over various terrains with a focus on safety and style. They aim to transform mobility into a source of joy, drawing inspiration from their roots in the Nuon Solar Challenge to innovate the world of mobility scooters.
Tessellate Bio is focused on redefining synthetic lethality in cancer treatment, aiming to extend beyond traditional homologous recombination deficiency targets to address areas of high medical need with new approaches. They combine cutting-edge research with drug development expertise to create a pipeline of first-in-class medicines, emphasizing tumor-agnostic treatments and precision medicine.
CardiacBooster is focused on developing the next generation of percutaneous left ventricular assist devices, aiming to minimize organ damage and increase survival chances after heart attacks. They are part of the Medtech Innovator Accelerator Class of 2021, reflecting their innovative approach to enhancing cardiac support technologies.
Phosphoenix is a pioneering medical device startup dedicated to restoring functional and life-enhancing vision to individuals who are blind due to non-functional retinas or optic nerves by developing a visual prosthesis that interfaces directly with the brain. Leveraging breakthroughs in electrode design and microelectronics from decades of neuroscientific research, they aim to enable blind people to identify objects, navigate independently, and regain autonomy in daily life.
Prolira specializes in the early detection and monitoring of acute encephalopathy and delirium with their DeltaScan® Brain State Monitor, offering a rapid and objective measurement that has a high diagnostic value for timely interventions. This technology aims to improve healthcare for older patients by enabling earlier and more accurate diagnosis of these conditions, which are common post-operative complications and can significantly impact patient outcomes.
Orthros Medical is a Dutch biotech company specializing in developing therapeutics and diagnostics for both animal and human health, with a focus on osteoarthritis. They utilize VHH-based (single chain antibodies) technology to explore new treatments and diagnostics, leveraging the unique properties of VHH for potential new local treatments.
Hybridize Therapeutics focuses on developing kidney-targeted RNA-based therapies for patients with acute and chronic kidney diseases, aiming to protect kidneys with high target specificity. Their approach leverages RNA therapeutics' power for cell type specific delivery, particularly improving the therapeutic window for untreated kidney diseases.
ShanX Medtech is developing KAIROS, a groundbreaking in-specimen device aimed at revolutionizing the way bacterial infections are diagnosed and treated by providing quick, evidence-based antibiotic susceptibility testing (AST) and diagnostics (Dx). This technology aims to enable healthcare providers to prescribe the correct antibiotic treatment promptly, addressing the challenge of antimicrobial resistance (AMR) and improving patient outcomes.
Onera Health is redefining sleep diagnostics and monitoring with its first self-applied, no-wire Polysomnography solution, the Onera Sleep Test System (STS). This patch-based sensor system captures all necessary signals for comprehensive sleep analysis, offering gold-standard, clinical-grade diagnostics and monitoring from the comfort of home or in clinical settings.
Vitestro develops autonomous blood drawing technology aimed at transforming patient care by reducing healthcare workers' workload and ensuring accurate, secure blood collection through AI and robotic innovation. Their device combines AI-based, ultrasound-guided imaging with robotic needle insertion, fully automating the blood drawing process from tourniquet application to bandaging, enhancing patient experience and clinical efficiency.
Tagworks Pharmaceuticals specializes in developing Click-to-Release technology for in vivo click chemistry, aiming to enhance efficacy and reduce toxicity in systemic treatments. Their technology focuses on controlled drug release, notably improving the therapeutic utility of potent systemic therapies, such as antibody-drug conjugates within the tumor microenvironment.
NecstGen, the Netherlands Center for the Clinical Advancement of Stem Cell and Gene Therapies, operates a state-of-the-art facility focused on the development and GMP manufacturing of cell and gene therapies. They support a wide range of organizations, from academic to industrial therapy developers, in translating research and early-stage clinical programs into treatments.
Pro Parents supports working parents and their employers by providing tools such as coaching, training, and expert networks to help balance work and family life. They aim to foster inclusive workplaces through personalized technology and specialist support, enhancing satisfaction and productivity for today's and tomorrow's working parents.
GreenIPP is a European Renewable Energy Development & Investment company that facilitates green power-producing projects across the continent. They serve as a one-stop service company for roof and landowners looking to rent out their property for green energy production, leveraging an extensive international network and strong local partnerships to offer comprehensive solutions throughout the entire supply chain.
Meatable is pioneering the development of lab-grown meat using a proprietary platform that initiates the natural process of muscle and fat growth, starting from a single animal cell. Their technology promises to deliver real meat without the need to raise and slaughter animals, making it a groundbreaking step towards a more sustainable food system.
RespiQ is developing a non-invasive, AI-enhanced breathalyzer for real-time health monitoring at home or point of care, focusing on detecting biomarkers for specific health issues through daily breath analysis. Their technology aims to provide early warnings for health issues, enabling personalized health management and improving overall well-being.
Caelus Health is a biotech company dedicated to developing microbiota-based products for the prevention and treatment of cardiometabolic disorders, including diabetes. They focus on the commercialization of interventions through a solid preclinical and early-stage clinical development approach, utilizing in-depth knowledge of the microbiome to address unmet medical needs.
Pan Cancer T is an immunotherapy company focused on developing next-generation TCR-T cell therapies for treating solid cancers. Their innovative approach leverages genetically modified T cells aimed at unique tumor-selective targets, with a pipeline that includes treatments for multiple solid tumors, promising more durable clinical responses.
Emproof specializes in providing advanced security solutions for embedded systems, ensuring high levels of software security and intellectual property integrity through their product, Emproof Nyx. This technology protects against reverse engineering and exploitation attacks across various industries, including Industrial IoT, semiconductors, automotive, aviation, and healthcare, by securing devices throughout their lifecycle.
VitroScan is a Dutch life sciences company that specializes in providing predictive testing solutions using ex vivo 3D micro tumor testing to evaluate patients' sensitivity to therapeutics. Their technology integrates advanced tumor testing within the native tumor microenvironment and AI algorithms to enhance drug efficacy evaluation and patient stratification for clinical trials, aiming to support the development of novel therapies.
Neolook specializes in offering video-augmentation services to support bonding and family connections in neonatal and pediatric care. Their platform, S2S, includes solutions for family engagement, academic research, and professional integration into existing medical devices and equipment, aiming to enhance clinical practice and scientific advancement through technology.
Citryll is a Dutch biotech company focusing on innovative treatments for autoimmune and other inflammatory diseases by targeting and inhibiting the formation and effects of neutrophil extracellular traps (NETs). Their main therapeutic candidate, CIT-013, is a human antibody designed to interfere with NET formation and promote their clearance, offering potential treatments for conditions like lupus, rheumatoid arthritis, and vasculitis.
eSIM Go empowers businesses of all sizes to offer their own digital connectivity solutions quickly and easily, leveraging eSIM technology to meet the changing communication needs. They provide API integration for mobile connectivity across 1,000 networks in over 150 countries, supporting industries like travel, fintech, and enterprise with flexible global connectivity options.
Spatium Medical, an innovative spin-off from Erasmus MC in Rotterdam, is developing the next generation of insufflation technology aimed at enhancing surgical procedures. Their focus on advanced insufflation methods highlights their commitment to improving clinical outcomes and patient safety in the operating room.
Solynta is pioneering in the field of potato breeding with its innovative hybrid potato breeding technology, which unlocks the true potential of potatoes, enhancing their nutritional value through new hybrid varieties. This technology aims to improve global food security and grower well-being by enabling the rapid development of potatoes with improved characteristics, such as increased disease resistance and yield.
Scenic Biotech is dedicated to harnessing the potential of genetic modifiers for the development of innovative treatments targeting cancer and rare genetic diseases. By exploring the body's intrinsic defense mechanisms against these conditions, their cutting-edge research aims to pave the way for groundbreaking therapeutics that could significantly impact patient care.
20Med Therapeutics is advancing the field of non-viral drug delivery with their proprietary bio-responsive polymeric nanoparticles (PNPs), designed for effective delivery of RNA and DNA payloads. They are focused on developing RNA and DNA-based vaccines and therapeutics, aiming to improve global access to medical innovations and address the distribution inequities, with a platform that offers significant advantages in manufacturing scalability, stability, and immunogenicity.
Delta Diagnostics is focused on making label-free, multiplexed biosensing technology accessible and affordable for all types of research, aiming to accelerate scientific discovery by providing faster, more efficient data gathering from precious samples. By integrating photonic integrated circuits, they offer a solution that significantly speeds up research workflows and reduces the cost of ownership, thus democratizing high-performance label-free detection for a wide range of scientific fields.
Audion Therapeutics is a clinical-stage biopharmaceutical company dedicated to developing therapies for hearing loss, focusing on restoring hearing function through targeting the gamma secretase protein complex. Their lead product candidate has completed early clinical studies, showing safety and initial indications of efficacy in patients with sensorineural hearing loss.
Toxys is a Dutch biotech company that specializes in providing innovative in vitro toxicity screening solutions, designed to rapidly identify hazardous and potential carcinogenic properties of new compounds during the early phases of product and drug development. Their services aim to help customers make informed decisions in the drug development pipeline, reducing the need for animal testing and contributing to the creation of safer medicines and products.
Xinvento is dedicated to improving the lives of individuals with congenital hyperinsulinism by researching and developing credible alternative treatments. Their goal is to enhance accessibility to modern medicine for these patients, thus improving the quality of life for both the patients and their caregivers.